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Cell reports, 7 3 , pp. Jego, Sonia ; Adamantidis, Antoine Roger MCH neurons: vigilant workers in the night. Sleep, 36 12 , pp.

American Academy of Sleep Medicine Jego, Sonia ; Glasgow, Stephen D. Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus. Nature neuroscience, 16 11 , pp.


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Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nature neuroscience, 16 7 , pp. Control of ventricular ciliary beating by the melanin concentrating hormone-expressing neurons of the lateral hypothalamus: a functional imaging survey. Frontiers in endocrinology, 4, p. Frontiers Research Foundation Carter, Matthew E.

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Functional wiring of hypocretin and LC-NE neurons: implications for arousal. Frontiers in behavioral neuroscience, 7 43 , p.

The role of melanin-concentrating hormone in conditioned reward learning. European journal of neuroscience, 36 8 , pp. Journal of neuroscience, 32 36 , pp. Society for Neuroscience Shining light on wakefulness and arousal.

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Biological psychiatry, 71 12 , pp. Analysis of Neuronal Circuits with Optogenetics. In: Morozov, Alexei ed. Controlled Genetic Manipulations. Totowa, NJ: Humana Press Neuron, 72 4 , pp.

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Optogenetic disruption of sleep continuity impairs memory consolidation. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. Journal of neuroscience, 31 30 , pp. Adamantidis, Antoine Roger ; de Lecea, Luis In: Baumann, Christian R. Narcolepsy: Pathophysiology, Diagnosis, and Treatment pp. New York: Springer Tuning arousal with optogenetic modulation of locus coeruleus neurons.

Nature neuroscience, 13 12 , pp. Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor Journal of neurophysiology, 3 , pp. American Physiological Society Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nature protocols, 5 3 , pp. Optogenetic deconstruction of sleep-wake circuitry in the brain. Frontiers in molecular neuroscience, 2, p. A role for Melanin-Concentrating Hormone in learning and memory.

Peptides, 30 11 , pp. Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. Journal of neuroscience, 29 35 , pp. Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. The hypocretins as sensors for metabolism and arousal. Journal of physiology, 1 , pp. Wiley-Blackwell Sleep and metabolism: shared circuits, new connections. Trends in endocrinology and metabolism, 19 10 , pp.

Elsevier Current Trends Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice. European journal of neuroscience, 27 7 , pp. Neural substrates of awakening probed with optogenetic control of hypocretin neurons.

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Nature, , pp. Macmillan Journals Ltd. Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function. European journal of neuroscience, 21 10 , pp. Home Statistics. Jump to: Provide Feedback. After novel advances, such as the description of the binding pockets, and ligand developments, more researchers are focusing on orexin receptors as promising targets.

Furthermore, targeting these receptors may provide therapeutic solutions for some health problems, other than sleep-wakefulness disorders including some psychiatric disorders and neurodegenerative diseases.


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We have also reviewed examples about other orexinergic system-related disorders. We use cookies to help provide and enhance our service and tailor content and ads.

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By continuing you agree to the use of cookies. Download PDF Download. Author links open overlay panel Abdelaziz Ghanemi a b Xintian Hu a c.